Jan 06, · Seroquel XR is used to treat bipolar disorder (manic depression) in adults and children who are at least 10 years old. Seroquel XR is also used together with antidepressant medications to treat major depressive disorder in adults. Seroquel XR may also be used for purposes not listed in this medication guide. This medicationis used to treat certain mental/mood conditions (such as schizophrenia, bipolar disorder, sudden episodes of maniaor depressionassociated with bipolar disorder). Quetiapineis known.
Quetiapinesold under the brand name Seroquel among others, is an atypical antipsychotic medication used for the treatment of schizophreniabipolar disorderand what are the uses for seroquel depressive disorder. Common side effects include sleepiness, constipationweight gain, and dry mouth. Quetiapine was developed in and approved for medical use in the United States in Quetiapine is primarily used to treat schizophrenia or bipolar disorder. A Cochrane review compared quetiapine to typical antipsychotics:.
In a comparison of 15 antipsychotics in effectiveness in treating schizophrenia, quetiapine demonstrated standard effectiveness. It is debatable whether, as a class, typical or atypical antipsychotics are more effective. A Cochrane review comparing quetiapine to other atypical antipsychotic agents tentatively concluded that it may be less efficacious than olanzapine and risperidone ; produce fewer movement related side effects than paliperidonearipiprazoleziprasidonerisperidone and olanzapine; and produce weight gain similar to risperidone, clozapine and aripiprazole.
They concluded that it produces suicide attempt, suicide; death; QTc prolongation, low blood pressure ; tachycardia ; sedation; gynaecomastia ; galactorrhoeamenstrual irregularity and white blood cell count at a rate similar to first generation antipsychotics.
In those with bipolar disorderquetiapine is used to treat depressive episodes; acute manic episodes associated with bipolar I disorder as either monotherapy or adjunct therapy to lithium ; valproate or lamotrigine ; acute mixed episodes; and maintenance treatment of bipolar I disorder as adjunct therapy to lithium or divalproex. Quetiapine is effective when used by itself  and when used along with other medications in major depressive disorder MDD.
Quetiapine does not decrease agitation among people with Alzheimer's. Quetiapine worsens intellectual functioning in the elderly with dementia and therefore is not recommended.
The use of low doses of quetiapine for insomniawhile common, is not recommended; there is little evidence of benefit and concerns regarding adverse effects. It is sometimes used off-labeloften as an augmentation agent, to treat conditions such as Tourette syndrome musical hallucinations  and anxiety disorders. Quetiapine and clozapine are the most widely used medications for the treatment of Parkinson's disease psychosis due to their very low extrapyramidal side-effect liability.
Owing to the risks associated with clozapine e. Sources for incidence lists:      . Both typical and atypical antipsychotics can cause tardive dyskinesia.
Weight gain can be a problem for some, with quetiapine causing more weight gain than fluphenazinehaloperidolloxapinemolindoneolanzapinepimoziderisperidonethioridazinethiothixenetrifluoperazineand ziprasidonebut less than chlorpromazineclozapineperphenazineand sertindole.
As with some other anti-psychotics, quetiapine may lower the seizure threshold and should be taken with caution in combination with drugs such as bupropion. The British National Formulary recommends a gradual withdrawal when discontinuing antipsychotics to avoid acute withdrawal syndrome or rapid relapse. There is tentative evidence that discontinuation what are the uses for seroquel antipsychotics can result in psychosis. Placental exposure is least for quetiapine compared to other atypical antipsychotics.
In contrast to most other antipsychotic drugs, which tend to be somewhat aversive and often show problems with patient compliance with prescribed medication regimes, quetiapine is sometimes associated with drug misuse and abuse potential, for its hypnotic and sedative effects. To a significantly greater extent than other atypical antipsychotic drugs, quetiapine was found to be associated with drug-seeking behaviors, and to have standardised street prices and slang terms associated with it, either by itself or in combination with other drugs such as "Q-ball" for the intravenous injection of quetiapine mixed with cocaine.
The pharmacological basis for this distinction from other second generation antipsychotic drugs is unclear, though it has been suggested that quetiapine's comparatively lower dopamine receptor affinity and strong antihistamine activity might mean it could be regarded as more similar to sedating antihistamines in this context.
While these issues have not been regarded as sufficient cause for placing quetiapine under increased legal how to find death records in texas, prescribers have been urged to show caution when prescribing quetiapine to individuals with characteristics that might place them at increased risk for drug misuse.
Most instances of acute overdosage result in only sedation, hypotension and tachycardia, but cardiac arrhythmia, coma and death have occurred in adults. Quetiapine has the following pharmacological actions:        . This means quetiapine is a dopamineserotoninand adrenergic antagonist, and a potent antihistamine with some anticholinergic properties. When the dose is increased, quetiapine activates the adrenergic system and binds strongly to serotonin receptors and autoreceptors.
At high doses, quetiapine starts blocking significant amounts of dopamine receptors. When treating schizophrenia, antagonism of D2 receptor by quetiapine in the mesolimbic pathway relieves positive symptoms and antagonism of the 5HT2A receptor in the frontal cortex of the brain relieves negative symptoms. Peak levels of quetiapine occur 1. Quetiapine is a tetracyclic compound and is closely related structurally to clozapineolanzapineloxapineand other tetracyclic antipsychotics.
The synthesis of quetiapine begins with a dibenzothiazepinone. The lactam is first treated with phosphoryl chloride to produce a dibenzothiazepine. A nucleophilic substitution is used to introduce the sidechain. AstraZeneca submitted a new drug application for a sustained-release version of quetiapine in the United States, Canada, and the European Union in the second half of for treatment of schizophrenia. The sustained-release quetiapine is marketed mainly as Seroquel XR.
On May 18,AstraZeneca announced that the U. According to AstraZeneca, Seroquel XR is "the first medication approved by the FDA what are victorian houses made of the once-daily acute treatment of both depressive and manic episodes associated with bipolar.
On December 24,AstraZeneca notified shareholders that the FDA had asked for additional information on the company's application to expand the use of sustained-release quetiapine for treatment of depression.
In the United States, the Food and Drug Administration FDA has approved quetiapine for the treatment of schizophrenia and of acute manic episodes associated with bipolar disorder bipolar mania and for treatment of bipolar depression.
Quetiapine received its initial indication from U. FDA for treatment of schizophrenia in Patent protection for the product ended in ; however, in a number of regions, the long-acting version remained under patent until In Aprilthe U. AstraZeneca then used those studies and articles as the basis for promotional messages about unapproved uses of Seroquel. Multiple lawsuits have been filed in relation to quetiapine's side-effects, in particular, diabetes. Approximately 10,  lawsuits  have been filed against AstraZeneca, alleging that quetiapine caused how to print in pages ranging from slurred speech and chronic insomnia to deaths.
Ina young man named Dan Markingson committed suicide in a controversial Seroquel clinical trial at the University of Minnesota while under an involuntary commitment order. One of the new batches contained Seroquel XL 50 mg tablets and one contained the Pfizer product Neurontin mg capsules.
From Wikipedia, the free encyclopedia. Atypical antipsychotic medication. AU : B3. IUPAC name. DB Y. D Y. Interactive image. Prolonged QT interval had an odds ratio for prolonging the QT interval over placebo of 0. Jaundiceyellowing of the eyes, skin and mucous membranes due to an impaired ability of the body to clear bilirubin, a by product of haem breakdown. Pancreatitispancreas swelling. Agranulocytosisa potentially fatal drop in white blood cell count. Leukopeniaa how to draw a shelby gt500 in white blood cell count, not as severe as agranulocytosis.
Neutropeniaa drop in neutrophils, the cell of the immune cells that defends the body against bacterial infections. Eosinophilia Anaphylaxisa potentially fatal allergic reaction. Seizure Hypothyroidismunderactive thyroid gland. Myocarditisswelling of the myocardium. Cardiomyopathy Hepatitisswelling of the liver.
Suicidal ideation Priapism. A prolonged and painful erection. Stevens—Johnson syndrome. A potentially fatal skin reaction. Medscape Reference. Archived from the original on 20 October Retrieved 11 October January Retrieved 20 October DrugPoint System Internet [cited Sep 18].
Ascend Laboratories, LLC. October Archived from the original on 2 December Retrieved 26 November McGraw Hill Professional. ISBN Archived from the original on 29 August Retrieved 26 March PMID American Journal of Health-System Pharmacy. S2CID Neuropsychiatric Disease and Treatment. PMC British Medical Association. Retrieved 18 What is peculiarly effective about the expressions crooked hands Archived from the original on 10 February Retrieved 3 April Drug Safety.
1. How it works
Dec 10, · Quetiapine is a medicine used to treat mental health disorders, including schizophrenia, bipolar disorder, and depression. This medicine is in a class of drugs called atypical antipsychotics. It /5. Apr 13, · Overview Seroquel (Quetiapine) is used to treat certain mood and mental conditions, including bipolar disorder (also known as bipolar), schizophrenia, as well as sudden episodes of mania Author: Psych Central Staff.
Medically reviewed by Carmen Fookes, BPharm. Last updated on Nov 5, If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:. Note: In general, seniors or children, people with certain medical conditions such as liver or kidney problems, heart disease, diabetes, seizures or people who take other medications are more at risk of developing a wider range of side effects.
View complete list of side effects. Seroquel is an antipsychotic that helps to calm and relieve psychotic thoughts. It is often given because it is quite sedating; however, care is needed because it also lowers blood pressure. Medicines that interact with Seroquel may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Seroquel.
An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed. Seroquel is metabolized through CYP3A4 hepatic enzymes.
Dosage decreases up to one-sixth of the Seroquel dose are usually necessary when given with CYP3A4 inhibitors. Dosage increases up to fivefold are usually necessary when given with CYP3A4 inducers.
Note that this list is not all-inclusive and includes only common medications that may interact with Seroquel. You should refer to the prescribing information for Seroquel for a complete list of interactions.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Seroquel only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Patient Tips Seroquel Print Save. How it works Seroquel is a brand trade name for quetiapine. Quetiapine acts on numerous receptors in the brain to calm and help diminish psychotic thoughts.
The exact way it works is unknown; however, some experts believe its mood calming effects may be through antagonism of dopamine and serotonin receptors. Quetiapine may also affect histamine receptors responsible for its side effect of sedation and adrenergic alpha1 receptors responsible for the fall in blood pressure when standing.
Seroquel belongs to the class of medicines known as atypical antipsychotics. Upsides Seroquel may be used in the treatment of schizophrenia in adults and children over the age of 13 years. Seroquel may also be used to treat bipolar disorder in adults and children over the age of Its ability to also calm and make people sleepy means it may be used in addition to antidepressants or to treat other conditions off-label uses include anxiety disorder.
Seroquel is available as a generic under the name of quetiapine. Downsides If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Confusion, headache, drowsiness, agitation, constipation, weight gain, dry mouth, and blurred vision. Sedation - which may affect your ability to drive or operate machinery. Avoid alcohol. May cause a lowering of blood pressure - this may be particularly noticeable when going from a sitting to a standing position and may increase the risk of falls.
Seroquel may also increase blood pressure in some people. Should not be used in seniors with dementia-related psychosis because it increases their risk of death.
Interaction or overdosage may cause serotonin syndrome symptoms include mental status changes [such as agitation, hallucinations, coma, delirium], fast heart rate, dizziness, flushing, muscle tremor or rigidity, and stomach symptoms [including nausea, vomiting, diarrhea].
Another serious syndrome called Neuroleptic Malignant Syndrome NMS has also been reported; symptoms include high body temperature, muscle rigidity, and mental disturbances; discontinue Seroquel immediately and seek urgent medical advice if symptoms of NMS develop. May increase the risk of bleeding, especially if used with other drugs that also increase bleeding risk. May also cause anxiety, nervousness, or insomnia. There is a risk of tardive dyskinesia uncontrollable, repetitive, facial movements associated with all antipsychotics, including Seroquel.
Significant weight loss has been reported, although may cause weight gain in some people. May precipitate a manic episode in people with undiagnosed bipolar disorder. May cause a lowering of total body sodium hyponatremia ; elderly people or people taking diuretics or already dehydrated may be more at risk.
May cause a discontinuation syndrome if abruptly stopped; symptoms include irritability, low mood, dizziness, electric shock sensations, headache, and confusion. High blood sugar levels that may lead to the development of diabetes and elevations in cholesterol or triglyceride levels have been reported.
Hypothyroidism low thyroid levels associated with Seroquel use may also occur. As with similar medications, Seroquel may increase the risk of suicidal thoughts or behavior in young adults; the risk is higher in those aged less than The extended-release form of Seroquel should not be given to anyone younger than 18 years.
View complete list of side effects 4. Bottom Line Seroquel is an antipsychotic that helps to calm and relieve psychotic thoughts. Tips Immediate-release tablets can be administered either with or without food. Administer extended-release tablets in the evening either without food or following a light meal. Swallow extended-release tablets whole, do not crush or chew. Initially, lower dosages are administered.
These are gradually increased as needed so that tolerance develops to side effects such as drowsiness or low blood pressure. Get up slowly when going from a lying or sitting position to standing. Seroquel may be given once a day or given multiple times a day depending on your doctor's instructions and the type of tablet given for example, immediate vs extended-release.
Do not drive or operate machinery or perform hazardous tasks if Seroquel makes you sleepy. Talk to your doctor if you feel that your mood is worsening or you feel agitated or are having suicide-related thoughts.
Avoid alcohol while taking Seroquel and keep hydrated. Avoid over-exercising. Tell your doctor if you experience any abnormal facial movements. Response and Effectiveness Peak levels of Seroquel are reached 1. Sedative effects happen almost immediately; however, it may take up to two to three weeks to see some improvement in other symptoms and up to six weeks for the full effects to be seen.
Interactions Medicines that interact with Seroquel may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Seroquel.
Common medications that may interact with Seroquel include: amiodarone clozapine CYP3A4 inducers, such as carbamazepine, oxcarbazepine, phenytoin, rifampin, St John's Wort CYP3A4 inhibitors, such as clarithromycin, cyclosporine, fluconazole, ketoconazole, nefazodone, ritonavir, tamoxifen, verapamil dexamethasone, methylprednisone, and prednisone HIV medications, such as indinavir, nelfinavir, and ritonavir medications used to treat Parkinson's Disease, such as cabergoline and levodopa other antidepressants or antipsychotics methadone sotalol valproate.
Avoid drinking alcohol or taking illegal or recreational drugs while taking Seroquel. References Seroquel quetiapine fumarate [Package Insert]. AstraZeneca Pharmaceuticals LP. Drug Status Availability Prescription only Rx. Drug Class. Atypical antipsychotics. Related Drugs. Subscribe to our newsletters. FDA Safety Alerts for all medications.