Estradiol / norethindrone Side Effects
Incidence not known. Abdominal or stomach cramps or pain. acid or sour stomach. anxiety. backache. belching. blistering, peeling, or loosening of the skin. bloating. blurred vision. breast tenderness, enlargement, pain, or discharge. change in vaginal discharge. Mar 16, · Dizziness. drowsiness. nausea. stomach pain. tenderness of the breasts. unusual tiredness or weakness. vomiting. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Medically reviewed by Drugs. Written by Cerner Multum. Estradiol a form of estrogen and progesterone are female hormones. Estradiol and progesterone is a combination medicine used to treat moderate to severe hot flashes caused by menopause. Estradiol may increase your risk of developing a condition that may lead to uterine cancer.
Call your doctor if you estradlol any vaginal bleeding. Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Estradiol and progesterone od not be used to prevent heart disease, stroke, or dementia. Estrogens can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterolif you are overweightor if you smoke.
Estrogens may also increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time.
Any doctor or surgeon who treats you should know that you are using estradiol and progesterone. Your doctor should check your progress on a regular basis every 3 to 6 months estradiool determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis and have a mammogram every year while using estradiol and progesterone. Take the medicine with food as soon as you can, but skip what did hillary clinton say about bill clinton missed dose if your next dose is due in less than 2 hours.
Qre not take two doses at one time. Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while effectw estradiol and progesterone. Grapefruit may interact with this medicine and lead to unwanted side effects. Avoid the use of grapefruit products. Get emergency medical help if you have signs of an allergic reaction: hives ; difficult breathing; swelling of your face, lips, tongue, or throat. This is not a complete list of side effects and others may occur.
Call your doctor for medical advice about sjde effects. Use: Treatment of moderate to severe vasomotor symptoms due to menopause. Sometimes it is not safe wnat use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects effscts make the medications less effective. Many drugs can interact with estradiol and progesterone. This includes prescription and over-the-counter medicines, vitaminsand herbal products. Not all possible interactions thr listed in this medication guide.
Tell your doctor about all your current medicines and any medicine you start or stop using. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and effect this medication only for the indication prescribed. Always consult your healthcare provider to how to repair cast aluminum patio furniture the information displayed on this page applies effecs your personal circumstances.
Drug Status Availability Prescription only Rx. Drug Class. Sex hormone combinations. Related Drugs. Subscribe to our newsletters. FDA Safety Alerts for all medications. Daily MedNews.
Feb 19, · Common estradiol side effects may include: nausea, vomiting, diarrhea, stomach cramps; mood changes, sleep problems (insomnia); cold symptoms such as stuffy nose, sinus pain, sore throat; weight gain; headache, back pain, dizziness; breast pain; darkening of the skin or skin rash; thinning scalp. Feb 25, · Common side effects may include: nausea, vomiting, diarrhea, stomach cramps; mood changes, sleep problems (insomnia); cold symptoms such as stuffy nose, sinus pain, sore throat; weight gain; headache, back pain; breast pain; thinning scalp hair; or; vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding. Oct 26, · What Are Side Effects Associated with Using Estradiol? Abdominal cramping. Anxiety. Bloating. Breakthrough bleeding. Breast enlargement. Breast tenderness/ pain /swelling. Freckles or darkening of facial skin (melasma) Changes in menstrual periods. Delayed ejaculation. Depression.
Medically reviewed by Drugs. Last updated on July 8, Commonly reported side effects of estradiol include: cerebrovascular accident, infection, malignant neoplasm of breast, endometrium disease, headache, and mastalgia. Other side effects include: abdominal pain, limb pain, pruritus, sinusitis, nausea, skin rash, and vaginitis.
See below for a comprehensive list of adverse effects. Applies to estradiol: vaginal capsule liquid filled, vaginal cream, vaginal insert extended release, vaginal tablet. Estrogens increase the risk of endometrial cancer ; monitor for abnormal vaginal bleeding. Estrogens with or without progestins should not be used for the prevention of cardiovascular disease or dementia. Increased risks of myocardial infarction, stroke, invasive breast cancer , pulmonary emboli, and deep vein thrombosis in postmenopausal women 50 to 79 years of age have been reported.
An increased risk of developing probable dementia in postmenopausal women 65 years of age or older has also been reported in women receiving estrogen alone or estrogen combined with progestins. Risks should be assumed to be similar for other doses, combinations, and dosage forms of estrogens and progestins.
Estrogens, with or without progestins, should be prescribed at the lowest effective doses and for the shortest duration possible. Use of unopposed estrogens increases the risk of endometrial cancer, while addition of a progestin decreases the risk of endometrial hyperplasia. Rule out malignancy if abnormal vaginal bleeding develops. Do not use estrogen alone or in combination with progestin to prevent cardiovascular disease or dementia. There is an increased risk of cardiovascular disorders ie, DVT , pulmonary embolism , stroke, myocardial infarction with combination therapy in women 50 years or older, and an increased risk of dementia in women 65 years or older with estrogen monotherapy or combination therapy.
Combination therapy also increases the risk of invasive breast cancer. Prescribe estrogens with or without progestins at the lowest effective dose and for the shortest duration consistent with risks and treatment goals.
Along with its needed effects, estradiol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking estradiol:. Get emergency help immediately if any of the following symptoms of overdose occur while taking estradiol:.
Some side effects of estradiol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. Managing side effects general information For Healthcare Professionals Applies to estradiol: compounding powder, intramuscular solution, oral tablet, transdermal emulsion, transdermal film extended release, transdermal gel, transdermal spray, vaginal ring.
Postmarketing reports : Vaginal irritation, vaginal pain, genital pruritus, changes in bleeding pattern, pelvic pain , breast tenderness, vaginal ulceration, uterine fibroids [ Ref ]. Postmarketing reports : Abdominal distension [ Ref ]. Postmarketing reports : Deep vein thrombosis, changes in blood pressure [ Ref ].
Uncommon 0. Rare less than 0. Postmarketing reports : Migraine aggravated, paresthesia, dizziness [ Ref ]. Postmarketing reports : Endometrial cancer, breast cancer [ Ref ]. Postmarketing reports : Drug ineffectiveness, blood estrogen increase, fatigue, exacerbation of hereditary angioedema [ Ref ]. Postmarketing reports : Vaginismus, insomnia , anxiety, irritability [ Ref ]. Postmarketing reports : Urticaria , erythematous or pruritic rash, alopecia , hyperhidrosis , night sweats , contact dermatitis , eczema [ Ref ].
Postmarketing reports : Visual disturbances, contact lens intolerance [ Ref ]. Postmarketing reports : Cholestatic jaundice [ Ref ]. Postmarketing reports : Fluid retention [ Ref ]. Postmarketing reports : Anaphylactic reactions, hypersensitivity [ Ref ]. Postmarketing reports : Application site reaction [ Ref ]. Estradiol Vaginal Insert estradiol topical. Julian TM "Pseudoincontinence secondary to unopposed estrogen replacement in the surgically castrate premenopausal female.
Estrace estradiol. Boston Collaborative Drug Surveilance Program "Surgically confirmed gallbladder disease, venous thromboembolism, and breast tumors in relation to postmenopausal estrogen therapy. Rancho Bernardo, Calif, revisited. Belchetz PE "Hormonal treatment of postmenopausal women. Crane MG, Harris JJ "Estrogens and hypertension: effect of discontinuing estrogens on blood pressure, exchangeable sodium, and the renin-aldosterone system.
Ten-year follow-up from the Nurses' Health Study. Schwartz J, Freeman R, Frishman W "Clinical pharmacology of estrogens: cardiovascular actions and cardioprotective benefits of replacement therapy in postmenopausal women. Report of a large case-control study.
An independent pathology review supporting original risk estimate. Oppenheim G "A case of rapid mood cycling with estrogen: implications for therapy. Possible association with estrogen therapy. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA. Estradiol Side Effects Medically reviewed by Drugs. Consumer Professional In Summary Commonly reported side effects of estradiol include: cerebrovascular accident, infection, malignant neoplasm of breast, endometrium disease, headache, and mastalgia. Vaginal route Insert, Extended Release Use of unopposed estrogens increases the risk of endometrial cancer, while addition of a progestin decreases the risk of endometrial hyperplasia.
Managing side effects general information. References 1. Climara estradiol. Cerner Multum, Inc. Yuvafem estradiol topical. Drug Status Availability Prescription only Rx. Mylan Pharmaceuticals Inc. AvKare, Inc. Drug Class. Related Drugs.